Case definition and classification of leukodystrophies and leukoencephalopathies.

ABSTRACT:

Objective

An approved definition of the term leukodystrophy does not currently exist. The lack of a precise case definition hampers efforts to study the epidemiology and the relevance of genetic white matter disorders to public health.

Method

Thirteen experts at multiple institutions participated in iterative consensus building surveys to achieve definition and classification of disorders as leukodystrophies using a modified Delphi approach.

Results

A case definition for the leukodystrophies was achieved, and a total of 30 disorders were classified under this definition. In addition, a separate set of disorders with heritable white matter abnormalities but not meeting criteria for leukodystrophy, due to presumed primary neuronal involvement and prominent systemic mani

SUBMITTER: Vanderver A 

PROVIDER: S-EPMC4390457 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature