Calibration weighted estimation of semiparametric transformation models for two-phase sampling.

ABSTRACT: Two-phase designs are commonly used to subsample subjects from a cohort in order to study covariates that are too expensive to ascertain for everyone in the cohort. This is particularly true for the study of immune response biomarkers in vaccine immunology, where new, elaborate assays are constantly being developed to improve our understanding of the human immune responses to vaccines and how the immune response may protect humans from virus infection. It has long being recognized that if there exist variables that are correlated with expensive variables and can be measured for every subject in the cohort, they can be leveraged to improve the estimation efficiency for the effects of the expensive variables. In this research article, we developed an improved inverse probability weighted est

SUBMITTER: Fong Y 

PROVIDER: S-EPMC4390487 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature