Vaccine design via nonnegative lasso-based variable selection.

ABSTRACT: There are many different strains of malaria parasites, each represented by a unique sequence of amino acids. A desirable vaccine would match the amino acid sequence of the parasite antigen. Because of the three-dimensional structure of protein, not all sites in the amino acid sequence participate in the binding between the vaccine-induced antibody and the parasite antigen. Nor do all sites have equal importance. In this work, we apply a nonnegative lasso-based variable selection to identify the 'important' amino acid sites and evaluate their relative importance. We then define a metric, the functional coverage, to measure the 'effective' matching in the amino acid sequence between the vaccine and the parasite. With the variable selection procedure, development of a vaccine needs only to ta

SUBMITTER: Hu Z 

PROVIDER: S-EPMC4390489 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature