Global diversity lines - a five-continent reference panel of sequenced Drosophila melanogaster strains.

ABSTRACT: Reference collections of multiple Drosophila lines with accumulating collections of "omics" data have proven especially valuable for the study of population genetics and complex trait genetics. Here we present a description of a resource collection of 84 strains of Drosophila melanogaster whose genome sequences were obtained after 12 generations of full-sib inbreeding. The initial rationale for this resource was to foster development of a systems biology platform for modeling metabolic regulation by the use of natural polymorphisms as perturbations. As reference lines, they are amenable to repeated phenotypic measurements, and already a large collection of metabolic traits have been assayed. Another key feature of these strains is their widespread geographic origin, coming from Beijing, It

SUBMITTER: Grenier JK 

PROVIDER: S-EPMC4390575 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature