Drosophila melanogaster activating transcription factor 4 regulates glycolysis during endoplasmic reticulum stress.

ABSTRACT: Endoplasmic reticulum (ER) stress results from an imbalance between the load of proteins entering the secretory pathway and the ability of the ER to fold and process them. The response to ER stress is mediated by a collection of signaling pathways termed the unfolded protein response, which plays important roles in development and disease. Here we show that in Drosophila melanogaster S2 cells, ER stress induces a coordinated change in the expression of genes involved in carbon metabolism. Genes encoding enzymes that carry out glycolysis were up-regulated, whereas genes encoding proteins in the tricarboxylic acid cycle and respiratory chain complexes were down-regulated. The unfolded protein response transcription factor Atf4 was necessary for the up-regulation of glycolytic enzymes and Lac

SUBMITTER: Lee JE 

PROVIDER: S-EPMC4390581 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature