Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting.

ABSTRACT: Tumors kill patients not only through well-characterized perturbations to their local environment but also through poorly understood pathophysiological interactions with distant tissues. Here, we use a Drosophila tumor model to investigate the elusive mechanisms underlying such long-range interactions. Transplantation of tumors into adults induces robust wasting of adipose, muscle, and gonadal tissues that are distant from the tumor, phenotypes that resemble the cancer cachexia seen in human patients. Notably, malignant, but not benign, tumors induce peripheral wasting. We identify the insulin growth factor binding protein (IGFBP) homolog ImpL2, an antagonist of insulin signaling, as a secreted factor mediating wasting. ImpL2 is sufficient to drive tissue loss, and insulin activity is redu

SUBMITTER: Figueroa-Clarevega A 

PROVIDER: S-EPMC4390765 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature