Mathematical modeling and validation of glucose compensation of the neurospora circadian clock.

ABSTRACT: Autonomous circadian oscillations arise from transcriptional-translational feedback loops of core clock components. The period of a circadian oscillator is relatively insensitive to changes in nutrients (e.g., glucose), which is referred to as "nutrient compensation". Recently, a transcription repressor, CSP-1, was identified as a component of the circadian system in Neurospora crassa. The transcription of csp-1 is under the circadian regulation. Intriguingly, CSP-1 represses the circadian transcription factor, WC-1, forming a negative feedback loop that can influence the core oscillator. This feedback mechanism is suggested to maintain the circadian period in a wide range of glucose concentrations. In this report, we constructed a mathematical model of the Neurospora circadian clock incor

SUBMITTER: Dovzhenok AA 

PROVIDER: S-EPMC4390811 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature