Does expression of glucose transporter protein-1 relate to prognosis and angiogenesis in osteosarcoma?

ABSTRACT:

Background

The survival of patients who present with nonmetastatic extremity osteosarcoma has dramatically improved, but there are some patients who do not respond to chemotherapy. The ability to identify patients with a poorer prognosis might allow us to target different therapy for these patients. Glucose transporter protein-1 (Glut-1), one of the key factors in glucose metabolism, has been reported to be an independent prognostic factor in various tumors. However, little is known about the role of the Glut-1 pathway in osteosarcoma.

Questions/purposes

We asked (1) if Glut-1 expression is a prognostic marker for survival in patients with osteosarcoma, and (2) if there is a relationship between Glut-1 expression and tumor angiogenesis.

Patients and methods

Thirty-sev

SUBMITTER: Kubo T 

PROVIDER: S-EPMC4390948 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature