Incomplete immune reconstitution despite virologic suppression in HIV-1 infected children and adolescents.

ABSTRACT:

Objectives

Some perinatally infected children do not regain normal CD4(+) T-cell counts despite suppression of HIV-1 plasma viremia by antiretroviral therapy (ART). The frequency, severity and significance of these discordant treatment responses remain unclear.

Design

We examined the persistence of CD4(+) lymphocytopenia despite virologic suppression in 933 children (≥ 5 years of age) in the USA, Latin America and the Caribbean.

Methods

CD4(+) T-cell trajectories were examined and Kaplan-Meier methods used to estimate median time to CD4(+) T-cell count at least 500 cells/μl.

Results

After 1 year of virologic suppression, most (99%) children achieved a CD4(+) T-cell count of at least 200 cells/μl, but CD4(+) T-cell counts remained below 500 cells/μl after 1 and

SUBMITTER: Krogstad P 

PROVIDER: S-EPMC4391276 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature