Altered levels of circulating miRNAs are associated Schistosoma japonicum infection in mice.

ABSTRACT:

Background

Dioecious flatworms of the genus Schistosoma causes schistosomiasis, which is a major public health problem in developing countries. Acquiring detailed knowledge of schistosome-host interactions may aid in the development of novel strategies for schistosomiasis control. MicroRNAs (miRNAs) are involved in processes such as development, cell proliferation, metabolism, and signal transduction. Circulating miRNAs not only serve as a novel class of biomarkers of many diseases but also regulate target gene expression in recipient cells, which are similar to hormones.

Methods

In the present study, we used miRNA microarrays to determine the profile of circulating miRNAs associated with S. japonicum infection of mice. The biological functions of the altered levels of miRNA

SUBMITTER: Zhu L 

PROVIDER: S-EPMC4391475 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature