Epitope-focused peptide immunogens in human use adjuvants protect rabbits from experimental inhalation anthrax.

ABSTRACT:

Background

Anthrax represents a formidable bioterrorism threat for which new, optimized vaccines are required. We previously demonstrated that epitope-focused multiple antigenic peptides or a recombinant protein in Freund's adjuvant can elicit Ab against the loop neutralizing determinant (LND), a cryptic linear neutralizing epitope in the 2ß2-2ß3 loop of protective antigen from Bacillus anthracis, which mediated protection of rabbits from inhalation challenge with B. anthracis Ames strain. However, demonstration of efficacy using human-use adjuvants is required before proceeding with further development of an LND vaccine for testing in non-human primates and humans.

Methods

To optimize the LND immunogen, we first evaluated the protective efficacy and immune correlates associ

SUBMITTER: Oscherwitz J 

PROVIDER: S-EPMC4391504 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature