Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains.

ABSTRACT: The role of insulin in the brain is still not completely understood. In the periphery, insulin can decrease inflammation induced by lipopolysaccharide (LPS); however, whether insulin can reduce inflammation within the brain is unknown. Experiments administrating intranasal insulin to young and aged adults have shown that insulin improves memory. In our animal model of chronic neuroinflammation, we administered insulin and/or LPS directly into the brain via the fourth ventricle for 4 weeks in young rats; we then analyzed their spatial memory and neuroinflammatory response. Additionally, we administered insulin or artificial cerebral spinal fluid (aCSF), in the same manner, to aged rats and then analyzed their spatial memory and neuroinflammatory response. Response to chronic neuroinflammati

SUBMITTER: Adzovic L 

PROVIDER: S-EPMC4391678 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature