Quantification of diabetes comorbidity risks across life using nation-wide big claims data.

ABSTRACT: Despite substantial progress in the study of diabetes, important questions remain about its comorbidities and clinical heterogeneity. To explore these issues, we develop a framework allowing for the first time to quantify nation-wide risks and their age- and sex-dependence for each diabetic comorbidity, and whether the association may be consequential or causal, in a sample of almost two million patients. This study is equivalent to nearly 40,000 single clinical measurements. We confirm the highly controversial relation of increased risk for Parkinson's disease in diabetics, using a 10 times larger cohort than previous studies on this relation. Detection of type 1 diabetes leads detection of depressions, whereas there is a strong comorbidity relation between type 2 diabetes and schizophren

SUBMITTER: Klimek P 

PROVIDER: S-EPMC4391714 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature