Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis.

ABSTRACT:

Introduction

Pathological bone changes differ considerably between inflammatory arthritic diseases and most studies have focused on bone erosion. Collagen-induced arthritis (CIA) is a model for rheumatoid arthritis, which, in addition to bone erosion, demonstrates bone formation at the time of clinical manifestations. The objective of this study was to use this model to characterise the histological and molecular changes in bone remodelling, and relate these to the clinical disease development.

Methods

A histological and gene expression profiling time-course study on bone remodelling in CIA was linked to onset of clinical symptoms. Global gene expression was studied with a gene chip array system.

Results

The main histopathological changes in bone structure and inflamm

SUBMITTER: Denninger KC 

PROVIDER: S-EPMC4391727 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature