Age-stratified risk of unexpected uterine sarcoma following surgery for presumed benign leiomyoma.

ABSTRACT:

Background

Estimates of unexpected uterine sarcoma following surgery for presumed benign leiomyoma that use age-stratification are lacking.

Patients and methods

A retrospective cohort of 2,075 patients that had undergone myomectomy was evaluated to determine the case incidence of unexpected uterine sarcoma. An aggregate risk estimate was generated using a meta-analysis of similar studies plus our data. Database-derived age distributions of the incidence rates of uterine sarcoma and uterine leiomyoma surgery were used to stratify risk by age.

Results

Of 2,075 patients in our retrospective cohort, 6 were diagnosed with uterine sarcoma. Our meta-analysis revealed 8 studies from 1980 to 2014. Combined with our study, 18 cases of leiomyosarcoma are reported in 10,120 patie

SUBMITTER: Brohl AS 

PROVIDER: S-EPMC4391766 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature