A comparison of genome-wide DNA methylation patterns between different vascular tissues from patients with coronary heart disease.

ABSTRACT: Epigenetic mechanisms of gene regulation in context of cardiovascular diseases are of considerable interest. So far, our current knowledge of the DNA methylation profiles for atherosclerosis affected and healthy human vascular tissues is still limited. Using the Illumina Infinium Human Methylation27 BeadChip, we performed a genome-wide analysis of DNA methylation in right coronary artery in the area of advanced atherosclerotic plaques, atherosclerotic-resistant internal mammary arteries, and great saphenous veins obtained from same patients with coronary heart disease. The resulting DNA methylation patterns were markedly different between all the vascular tissues. The genes hypomethylated in athero-prone arteries to compare with atherosclerotic-resistant arteries were predominately involve

SUBMITTER: Nazarenko MS 

PROVIDER: S-EPMC4391864 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature