The epidemiological impact of HIV antiretroviral therapy on malaria in children.

ABSTRACT:

Objective

The objective of this study is to determine the epidemiological effectiveness of a first-line antiretroviral regimen with HIV protease inhibitor for preventing recurrent malaria in children under the range of HIV prevalence levels and malaria transmission intensities encountered in sub-Saharan Africa.

Design

A dynamic model of malaria transmission was developed using clinical data on the protease inhibitor extended posttreatment prophylactic effect of the antimalarial treatment, artemether-lumefantrine, in addition to parameter estimates from the literature.

Methods

To evaluate the benefits of HIV protease inhibitors on the health burden of recurrent malaria among children, we constructed a dynamic model of malaria transmission to both HIV-positive and HIV-n

SUBMITTER: Greenhalgh S 

PROVIDER: S-EPMC4391884 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature