Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer.

ABSTRACT:

Background

Characterisation of colorectal cancer (CRC) genomes by next-generation sequencing has led to the discovery of novel recurrently mutated genes. Nevertheless, genomic data has not yet been used for CRC prognostication.

Objective

To identify recurrent somatic mutations with prognostic significance in patients with CRC.

Method

Exome sequencing was performed to identify somatic mutations in tumour tissues of 22 patients with CRC, followed by validation of 187 recurrent and pathway-related genes using targeted capture sequencing in additional 160 cases.

Results

Seven significantly mutated genes, including four reported (APC, TP53, KRAS and SMAD4) and three novel recurrently mutated genes (CDH10, FAT4 and DOCK2), exhibited high mutation prevalence (6-14% fo

SUBMITTER: Yu J 

PROVIDER: S-EPMC4392212 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature