Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink.

ABSTRACT:

Objectives

To determine whether gout increases risk of incident coronary heart disease (CHD), cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of primary care patients with gout, since there have been no such large studies in primary care.

Methods

A retrospective cohort study was performed using data from the Clinical Practice Research Datalink (CPRD). Risk of incident CHD, CVD and PVD was compared in 8386 patients with an incident diagnosis of gout, and 39 766 age, sex and registered general practice-matched controls, all aged over 50 years and with no prior vascular history, in the 10 years following incidence of gout, or matched index date (baseline). Multivariable Cox Regression was used to estimate HRs and covariates included sex and baselin

SUBMITTER: Clarson LE 

PROVIDER: S-EPMC4392302 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature