Synchrotron radiation macromolecular crystallography: science and spin-offs.

ABSTRACT: A current overview of synchrotron radiation (SR) in macromolecular crystallography (MX) instrumentation, methods and applications is presented. Automation has been and remains a central development in the last decade, as have the rise of remote access and of industrial service provision. Results include a high number of Protein Data Bank depositions, with an increasing emphasis on the successful use of microcrystals. One future emphasis involves pushing the frontiers of using higher and lower photon energies. With the advent of X-ray free-electron lasers, closely linked to SR developments, the use of ever smaller samples such as nanocrystals, nanoclusters and single molecules is anticipated, as well as the opening up of femtosecond time-resolved diffraction structural studies. At SR source

SUBMITTER: Helliwell JR 

PROVIDER: S-EPMC4392420 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature