Reappraisal of the glycerol test in patients with suspected Meniere's disease.

ABSTRACT:

Background

Recent advances in magnetic resonance imaging make it possible to visualize the presumed pathophysiologic correlate of Menière's disease: endolymphatic hydrops. As traditional diagnostic tests can provide only indirect evidence, they are hardly competitive in this respect and need to be rethought. This is done here for the glycerol test.

Methods

The data of a previous retrospective analysis of the glycerol test in patients with suspected Menière's disease are reinterpreted using a simple model. The mean threshold reduction (MTR) in the frequency range from 125 to 1500 Hz (calculated from audiograms obtained immediately before and four hours after the glycerol intake) is used as the test statistic. The proposed model explains the frequency distribution of the obser

SUBMITTER: Lutkenhoner B 

PROVIDER: S-EPMC4392460 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature