Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice.

ABSTRACT:

Background

In mammals, white adipose tissue (WAT) stores fat and brown adipose tissue (BAT) dissipates fat to produce heat. Several studies showed that females have more active BAT. Members of the bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) families are expressed in BAT and are involved in BAT activity. We hypothesized that differential expression of BMPs and FGFs might contribute to sex differences in BAT activity.

Methods

We investigated the expression of BMPs and FGFs in BAT of male and female C57BL/6J mice upon gonadectomy, cold exposure, and exposure to sex steroids.

Results

Of the FGF family, BAT Fgf1, Fgf9, Fgf18, and Fgf21 expression was induced upon cold exposure, but only Fgf1 expression was obviously different between the sexes: fema

SUBMITTER: Grefhorst A 

PROVIDER: S-EPMC4392498 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature