Ontology highlight
ABSTRACT:
SUBMITTER: Zhang LJ
PROVIDER: S-EPMC4392603 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Carcinogenesis 20150109 4
Cancer gender disparity has been observed for a variety of human malignancies. Thyroid cancer is one such cancer with a higher incidence in women, but more aggressive disease in men. There is scant evidence on the role of sex hormones on cancer initiation/progression. Using a transgenic mouse model of follicular thyroid cancer (FTC), we found castration led to lower rates of cancer in females and less advanced cancer in males. Mechanistically, less advanced cancer in castrated males was due to i ...[more]