Preterm birth and random plasma insulin levels at birth and in early childhood.

ABSTRACT:

Importance

Although previous reports have linked preterm birth with insulin resistance in children and adults, it is not known whether altered insulin homeostasis is detectable at birth and tracks from birth through childhood.

Objective

To investigate whether preterm birth is associated with elevated plasma insulin levels at birth and whether this association persists into early childhood.

Design, setting, and participants

A prospective birth cohort of 1358 children recruited at birth from 1998 to 2010 and followed-up with prospectively from 2005 to 2012 at the Boston Medical Center in Massachusetts.

Main outcomes and measures

Random plasma insulin levels were measured at 2 time points: at birth (cord blood) and in early childhood (venous blood). The median age

SUBMITTER: Wang G 

PROVIDER: S-EPMC4392841 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature