Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma.

ABSTRACT:

Background

Survival rates for oesophageal adenocarcinoma (OAC) remain disappointingly poor and current conventional treatment modalities have minimal impact on long-term survival. This is partly due to a lack of understanding of the molecular changes that occur in this disease. Previous studies have indicated that the transcription factor FOXM1 is commonly upregulated in this cancer type but the impact of this overexpression on gene expression in the context of OAC is largely unknown. FOXM1 does not function alone but works alongside the antagonistically-functioning co-regulatory MMB and DREAM complexes.

Methods

To establish how FOXM1 affects gene expression in OAC we have identified the FOXM1 target gene network in OAC-derived cells using ChIP-seq and determined the express

SUBMITTER: Wiseman EF 

PROVIDER: S-EPMC4392876 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature