Development of Ss-NIE-1 recombinant antigen based assays for immunodiagnosis of strongyloidiasis.

ABSTRACT: Strongyloides stercoralis is a widely distributed parasite that infects 30 to 100 million people worldwide. In the United States strongyloidiasis is recognized as an important infection in immigrants and refugees. Public health and commercial reference laboratories need a simple and reliable method for diagnosis of strongyloidiasis to identify and treat cases and to prevent transmission. The recognized laboratory test of choice for diagnosis of strongyloidiasis is detection of disease specific antibodies, most commonly using a crude parasite extract for detection of IgG antibodies. Recently, a luciferase tagged recombinant protein of S. stercoralis, Ss-NIE-1, has been used in a luciferase immunoprecipitation system (LIPS) to detect IgG and IgG4 specific antibodies. To promote wider adoptio

SUBMITTER: Rascoe LN 

PROVIDER: S-EPMC4393093 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature