Low birth weight activates the renin-angiotensin system, but limits cardiac angiogenesis in early postnatal life.

ABSTRACT: Low birth weight (LBW) is associated with increased risk of adult cardiovascular disease and this association may be partly a consequence of early programming of the renin-angiotensin system (RAS). We investigated the effects of LBW on expression of molecules in the RAS and cardiac tissue remodeling. Left ventricular samples were collected from the hearts of 21 days old lambs that were born average birth weight (ABW) and LBW. Cardiac mRNA expression was quantified using real-time RT-PCR and protein expression was quantified using Western blotting. DNA methylation and histone acetylation were assessed by combined bisulfite restriction analysis and chromatin immunoprecipitation, respectively. There were increased plasma renin activity, angiotensin I (ANGI), and ANGII concentrations in LBW co

SUBMITTER: Wang KC 

PROVIDER: S-EPMC4393187 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature