Memantine monotherapy for Alzheimer's disease: a systematic review and meta-analysis.

ABSTRACT:

Background

We performed an updated meta-analysis of randomized placebo-controlled trials testing memantine monotherapy for patients with Alzheimer's disease (AD).

Methods

The meta-analysis included randomized controlled trials of memantine monotherapy for AD, omitting those in which patients were also administered a cholinesterase inhibitor. Cognitive function, activities of daily living, behavioral disturbances, global function, stage of dementia, drug discontinuation rate, and individual side effects were compared between memantine monotherapy and placebo groups. The primary outcomes were cognitive function and behavioral disturbances; the others were secondary outcomes.

Results

Nine studies including 2433 patients that met the study's inclusion criteria were identi

SUBMITTER: Matsunaga S 

PROVIDER: S-EPMC4393306 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature