Use of oral bisphosphonates in primary prevention of fractures in postmenopausal women: a population-based cohort study.

ABSTRACT:

Objective

To compare incidence of first osteoporotic fracture in two cohorts of postmenopausal women, one treated with bisphosphonates and the other only with calcium and vitamin D.

Design

Retrospective population cohort study with paired matching based on data from electronic health records.

Setting

Women aged 60 years and older in 2005, from 21 primary care centers in a healthcare region of Spain.

Participants

Two groups of women aged 60 years and older (n = 1208), prescribed either calcium and vitamin D (CalVitD) or bisphosphonates (BIPHOS) with or without calcium and vitamin D, were compared for the end point of first recorded osteoporotic-related fracture, with 5-years follow-up.

Main outcome measure

Incidence of first fracture: Vertebral fracture,

SUBMITTER: Real J 

PROVIDER: S-EPMC4393307 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature