Evolution of DOHaD: the impact of environmental health sciences.

ABSTRACT: Environmental exposures have a significant influence on the chronic health conditions plaguing children and adults. Although the Developmental Origins of Health and Disease (DOHaD) paradigm historically has focused on nutrition, an expanding body of research specifically communicates the effects of chemical exposures on early-life development and the propagation of non-communicable disease across the lifespan. This paper provides an overview of 20 years of research efforts aimed at identifying critical windows of susceptibility to environmental exposures and the signaling changes and epigenetic influences associated with disease progression. DOHaD grants funded by the National Institute of Environmental Health Sciences (NIEHS) in 1991, 2001 and 2011 are identified by grant-analysis softwar

SUBMITTER: Haugen AC 

PROVIDER: S-EPMC4393755 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature