Metabolic factors and genetic risk mediate familial type 2 diabetes risk in the Framingham Heart Study.

ABSTRACT:

Aims/hypothesis

Type 2 diabetes mellitus in parents is a strong determinant of diabetes risk in their offspring. We hypothesise that offspring diabetes risk associated with parental diabetes is mediated by metabolic risk factors.

Methods

We studied initially non-diabetic participants of the Framingham Offspring Study. Metabolic risk was estimated using beta cell corrected insulin response (CIR), HOMA-IR or a count of metabolic syndrome components (metabolic syndrome score [MSS]). Dietary risk and physical activity were estimated using questionnaire responses. Genetic risk score (GRS) was estimated as the count of 62 type 2 diabetes risk alleles. The outcome of incident diabetes in offspring was examined across levels of parental diabetes exposure, accounting for sibling corr

SUBMITTER: Raghavan S 

PROVIDER: S-EPMC4393775 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature