The immune system in hepatocellular carcinoma and potential new immunotherapeutic strategies.

ABSTRACT:

Background

Hepatocellular carcinoma is a major health problem worldwide and the third most common cause of cancer-related death. HCC treatment decisions are complex and dependent upon tumor staging. Several molecular targeted agents have been evaluated in clinical trials in advanced HCC. Despite of only modest objective response rates according to the Response Evaluation Criteria in Solid Tumors, several studies showed encouraging results in terms of prolongation of the time to progression, disease stabilization, and survival. Cellular immunotherapy would improve the immune state and has potential in enhancing the therapeutic outcome for HCC patients.

Materials and methods

A search of the literature was made using cancer literature, the PubMed, Scopus, and Web of Science (WO

SUBMITTER: Bertino G 

PROVIDER: S-EPMC4393929 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature