Frontal P3 event-related potential is related to brain glutamine/glutamate ratio measured in vivo.

ABSTRACT:

Background

The auditory P3 event-related potential (ERP) is thought to index cognitive processing relevant to attention and working memory processes. Drug challenge studies suggest that glutamate neurotransmission plays an important role in modulating P3 ERP. However, while direct links between glutamate activity and P3 ERP response in humans are suspected, mechanistic details remain largely unknown. We investigated here the relationships between P3 ERP and indices of glutamatergic processing measured in vivo with proton magnetic resonance spectroscopy ((1)H MRS). We hypothesized that a higher index of glutamatergic processing (glutamine/glutamate ratio; abbreviated Gln/Glu) in the anterior cingulate (ACC) and in the parietal-occipital (POC) cortices would associate with larger fro

SUBMITTER: Hall MH 

PROVIDER: S-EPMC4394009 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature