Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients.

ABSTRACT:

Aim

To investigate the effects of single nucleotide polymorphisms (SNPs) in glutathione S-transferase (GST) genes on survival of hepatocellular carcinoma (HCC) patients.

Methods

Twelve tagging SNPs in GST genes (including GSTA1, GSTA4, GSTM2, GSTM3, GSTO1, GSTO2 and GSTP1) were genotyped using Sequenom MassARRAY iPLEX genotyping method in a cohort of 214 Chinese patients with resected HCC. The Cox proportional hazards model and log-rank test were performed to determine the SNPs related to outcome. Additionally, stratified analysis was performed at each level of the demographic and clinical variables. An SNP-gene expression association model was further established to investigate the correlation between SNP and gene expression.

Results

Two SNPs (GSTO2: rs7085725 and GS

SUBMITTER: Qu K 

PROVIDER: S-EPMC4394094 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature