Glucocorticoids turn over slowly in human adipose tissue in vivo.

ABSTRACT:

Context

Lipophilic plasma glucocorticoids are thought to gain rapid access to intracellular compartments in adipose tissue. In other organs, transport can be regulated in a steroid- and tissue-specific manner. Moreover, 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) generates additional cortisol within adipose.

Aim

The aim was to measure the rate of exchange of cortisol between plasma and adipose for comparison with rates of intracellular cortisol generation by 11βHSD1.

Participants and interventions

With ethical approval, otherwise healthy females (n = 6) undergoing hysterectomy for benign indications were infused with tracer 9,11,12,12-[(2)H](4)cortisol (d4-cortisol). Adipose biopsies and peripheral venous samples were obtained during surgery after 3.9-5.5 h of i

SUBMITTER: Hughes KA 

PROVIDER: S-EPMC4394154 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature