Physiological consequences of abnormal connectivity in a developmental epilepsy.

ABSTRACT:

Objective

Many forms of epilepsy are associated with aberrant neuronal connections, but the relationship between such pathological connectivity and the underlying physiological predisposition to seizures is unclear. We sought to characterize the cortical excitability profile of a developmental form of epilepsy known to have structural and functional connectivity abnormalities.

Methods

We employed transcranial magnetic stimulation (TMS) with simultaneous electroencephalographic (EEG) recording in 8 patients with epilepsy from periventricular nodular heterotopia and matched healthy controls. We used connectivity imaging findings to guide TMS targeting and compared the evoked responses to single-pulse stimulation from different cortical regions.

Results

Heterotopia patie

SUBMITTER: Shafi MM 

PROVIDER: S-EPMC4394240 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature