Targeting histone deacetylases: perspectives for epigenetic-based therapy in cardio-cerebrovascular disease.

ABSTRACT: Although the pathogenesis of cardio-cerebrovascular disease (CCVD) is multifactorial, an increasing number of experimental and clinical studies have highlighted the importance of histone deacetylase (HDAC)-mediated epigenetic processes in the development of cardio-cerebrovascular injury. HDACs are a family of enzymes to balance the acetylation activities of histone acetyltransferases on chromatin remodeling and play essential roles in regulating gene transcription. To date, 18 mammalian HDACs are identified and grouped into four classes based on similarity to yeast orthologs. The zinc-dependent HDAC family currently consists of 11 members divided into three classes (class I, II, and IV) on the basis of structure, sequence homology, and domain organization. In comparison, class III HDACs (a

SUBMITTER: Wang ZY 

PROVIDER: S-EPMC4394331 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature