Functional genomic analysis reveals overlapping and distinct features of chronologically long-lived yeast populations.

ABSTRACT: Yeast chronological lifespan (CLS) is extended by multiple genetic and environmental manipulations, including caloric restriction (CR). Understanding the common changes in molecular pathways induced by such manipulations could potentially reveal conserved longevity mechanisms. We therefore performed gene expression profiling on several long-lived yeast populations, including anade4∆mutant defective in de novo purine (AMP) biosynthesis, and a calorie restricted WT strain. CLS was also extended by isonicotinamide (INAM) or expired media derived from CR cultures. Comparisons between these diverse long-lived conditions revealed a common set of differentially regulated genes, several of which were potential longevity biomarkers. There was also enrichment for genes that function in CLS regulatio

SUBMITTER: Wierman MB 

PROVIDER: S-EPMC4394729 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature