Plasma corin decreases after coronary artery bypass graft surgery and is associated with postoperative heart failure: a pilot study.

ABSTRACT:

Objective

Corin is a natriuretic peptide-converting enzyme that cleaves precursor pro-B-type natriuretic peptide to active B-type natriuretic peptide (BNP) (diuretic, natriuretic, and vasodilatory properties). Increased plasma BNP is a known diagnostic and prognostic heart failure (HF) biomarker in ambulatory and surgical patients. Recent studies indicate that plasma corin is decreased significantly in chronic HF patients, yet perioperative plasma corin concentrations have not been assessed in cardiac surgical patients. The objectives of this study were to determine the effect of coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) on plasma corin concentrations and to assess the association between change in perioperative plasma corin concentration and lon

SUBMITTER: Barnet CS 

PROVIDER: S-EPMC4394899 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature