Mechanical unloading promotes myocardial energy recovery in human heart failure.

ABSTRACT:

Background

Impaired bioenergetics is a prominent feature of the failing heart, but the underlying metabolic perturbations are poorly understood.

Methods and results

We compared metabolomic, gene transcript, and protein data from 6 paired samples of failing human left ventricular tissue obtained during left ventricular assist device insertion (heart failure samples) and at heart transplant (post-left ventricular assist device samples). Nonfailing left ventricular wall samples procured from explanted hearts of patients with right heart failure served as novel comparison samples. Metabolomic analyses uncovered a distinct pattern in heart failure tissue: 2.6-fold increased pyruvate concentrations coupled with reduced Krebs cycle intermediates and short-chain acylcarnitines, sugg

SUBMITTER: Gupte AA 

PROVIDER: S-EPMC4394989 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature