Fast and accurate construction of ultra-dense consensus genetic maps using evolution strategy optimization.

ABSTRACT: Our aim was to develop a fast and accurate algorithm for constructing consensus genetic maps for chip-based SNP genotyping data with a high proportion of shared markers between mapping populations. Chip-based genotyping of SNP markers allows producing high-density genetic maps with a relatively standardized set of marker loci for different mapping populations. The availability of a standard high-throughput mapping platform simplifies consensus analysis by ignoring unique markers at the stage of consensus mapping thereby reducing mathematical complicity of the problem and in turn analyzing bigger size mapping data using global optimization criteria instead of local ones. Our three-phase analytical scheme includes automatic selection of ~100-300 of the most informative (resolvable by recombi

SUBMITTER: Mester D 

PROVIDER: S-EPMC4395089 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature