Persistent DNA damage-induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells.

ABSTRACT: Human mesenchymal stem cells (hMSCs) are adult multipotent stem cells located in various tissues, including the bone marrow. In contrast to terminally differentiated somatic cells, adult stem cells must persist and function throughout life to ensure tissue homeostasis and repair. For this reason, they must be equipped with DNA damage responses able to maintain genomic integrity while ensuring their lifelong persistence. Evaluation of hMSC response to genotoxic insults is of great interest considering both their therapeutic potential and their physiological functions. This study aimed to investigate the response of human bone marrow MSCs to the genotoxic agent Actinomycin D (ActD), a well-known anti-tumour drug. We report that hMSCs react by undergoing premature senescence driven by a persi

SUBMITTER: Minieri V 

PROVIDER: S-EPMC4395188 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature