A mathematical model of collective cell migration in a three-dimensional, heterogeneous environment.

ABSTRACT: Cell migration is essential in animal development, homeostasis, and disease progression, but many questions remain unanswered about how this process is controlled. While many kinds of individual cell movements have been characterized, less effort has been directed towards understanding how clusters of cells migrate collectively through heterogeneous, cellular environments. To explore this, we have focused on the migration of the border cells during Drosophila egg development. In this case, a cluster of different cell types coalesce and traverse as a group between large cells, called nurse cells, in the center of the egg chamber. We have developed a new model for this collective cell migration based on the forces of adhesion, repulsion, migration and stochastic fluctuation to generate the m

SUBMITTER: Stonko DP 

PROVIDER: S-EPMC4395426 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature