Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration.

ABSTRACT:

Background

Ventilator-induced lung injury is a form of acute lung injury that develops in critically ill patients on mechanical ventilation and has a high degree of mortality. Nicotinamide phosphoribosyltransferase is an enzyme that is highly upregulated in ventilator-induced lung injury and exacerbates the injury when given exogenously. Nicotinamide (vitamin B3) directly inhibits downstream pathways activated by Nicotinamide phosphoribosyltransferase and is protective in other models of acute lung injury.

Methods

We administered nicotinamide i.p. to mice undergoing mechanical ventilation with high tidal volumes to study the effects of nicotinamide on ventilator-induced lung injury. Measures of injury included oxygen saturations and bronchoalveolar lavage neutrophil counts,

SUBMITTER: Jones HD 

PROVIDER: S-EPMC4395431 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature