Abnormal cortical growth in schizophrenia targets normative modules of synchronized development.

ABSTRACT:

Background

Schizophrenia is a disorder of brain connectivity and altered neurodevelopmental processes. Cross-sectional case-control studies in different age groups have suggested that deficits in cortical thickness in childhood-onset schizophrenia may normalize over time, suggesting a disorder-related difference in cortical growth trajectories.

Methods

We acquired magnetic resonance imaging scans repeated over several years for each subject, in a sample of 106 patients with childhood-onset schizophrenia and 102 age-matched healthy volunteers. Using semiparametric regression, we modeled the effect of schizophrenia on the growth curve of cortical thickness in ~80,000 locations across the cortex, in the age range 8 to 30 years. In addition, we derived normative developmental mo

SUBMITTER: Alexander-Bloch AF 

PROVIDER: S-EPMC4395469 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature