Ictal adipokines are associated with pain severity and treatment response in episodic migraine.

ABSTRACT:

Objective

To evaluate ictal adipokine levels in episodic migraineurs and their association with pain severity and treatment response.

Methods

This was a double-blind, placebo-controlled trial evaluating peripheral blood specimens from episodic migraineurs at acute pain onset and 30 to 120 minutes after treatment with sumatriptan/naproxen sodium vs placebo. Total adiponectin (T-ADP), ADP multimers (high molecular weight [HMW], middle molecular weight, and low molecular weight [LMW]), leptin, and resistin levels were evaluated by immunoassays.

Results

Thirty-four participants (17 responders, 17 nonresponders) were included. In all participants, pretreatment pain severity increased with every quartile increase in both the HMW:T-ADP ratio (coefficient of variation [CV] 0.

SUBMITTER: Chai NC 

PROVIDER: S-EPMC4395883 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature