Predicting the risk of mild cognitive impairment in the Mayo Clinic Study of Aging.

ABSTRACT:

Objective

We sought to develop risk scores for the progression from cognitively normal (CN) to mild cognitive impairment (MCI).

Methods

We recruited into a longitudinal cohort study a randomly selected, population-based sample of Olmsted County, MN, residents, aged 70 to 89 years on October 1, 2004. At baseline and subsequent visits, participants were evaluated for demographic, clinical, and neuropsychological measures, and were classified as CN, MCI, or dementia. Using baseline demographic and clinical variables in proportional hazards models, we derived scores that predicted the risk of progressing from CN to MCI. We evaluated the ability of these risk scores to classify participants for MCI risk.

Results

Of 1,449 CN participants, 401 (27.7%) developed MCI. A basic

SUBMITTER: Pankratz VS 

PROVIDER: S-EPMC4395890 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature