A genome-wide association study of copy-number variation identifies putative loci associated with osteoarthritis in Koreans.

ABSTRACT:

Background

OA is a complex disease caused by environmental and genetic risk factors. The purpose of this study is to identify candidate copy number variations (CNVs) associated with OA.

Methods

We performed a genome-wide association study of CNV to identify potential loci that confer susceptibility to or protection from OA. CNV genotyping was conducted using NimbleGen HD2 3 × 720K comparative hybridization array and included samples from 371 OA patients and 467 healthy controls. The putative CNV regions identified were confirmed with a TaqMan assay.

Results

We identified six genomic regions associated with OA encompassing CNV loci. None of six loci had previously been reported in genome-wide association studies with OA, although a genetic analysis suggested that they

SUBMITTER: Moon S 

PROVIDER: S-EPMC4395893 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature