Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice.

ABSTRACT:

Background

Nanoparticles have become a key technology in multiple industries. However, there are growing reports of the toxicity of nanomaterials to humans. In particular, nanomaterials have been linked to lung diseases. The molecular mechanisms of nanoparticle toxicity are largely unexplored.

Methods

Acute lung injury was induced in wild-type mice and angiotensin-coverting enzyme 2 (ACE2) knockout mice by the intratracheal instillation of cationic polyamidoamine dendrimer (PAMAM) nanoparticles. For rescue experiments, losartan (15 mg/kg in PBS) was injected intraperitoneally 30 min before nanoparticle administration.

Results

Some PAMAM nanoparticles, but not anionic PAMAM nanoparticles or carbon nanotubes, triggered acute lung failure in mice. Mechanistically, cation

SUBMITTER: Sun Y 

PROVIDER: S-EPMC4395934 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature