Response inhibition and response monitoring in a saccadic double-step task in schizophrenia.

ABSTRACT:

Background

Cognitive control impairments are linked to functional outcome in schizophrenia. The goal of the current study was to investigate precise abnormalities in two aspects of cognitive control: reactively changing a prepared response, and monitoring performance and adjusting behavior accordingly. We adapted an oculomotor task from neurophysiological studies of the cellular basis of cognitive control in nonhuman primates.

Methods

16 medicated outpatients with schizophrenia (SZ) and 18 demographically-matched healthy controls performed the modified double-step task. In this task, participants were required to make a saccade to a visual target. Infrequently, the target jumped to a new location and participants were instructed to rapidly inhibit and change their response.

SUBMITTER: Thakkar KN 

PROVIDER: S-EPMC4396187 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature